This is one of the best arthritis and pain cream sold at Edwards Pharmacy. According to Dr. Julian Whitaker, MD; Penetran contains nitrogen compounds called quaternary amines. The primary agent for most injectables anesthetics, including Lidocaine and Novocain, which gives it outstanding analgesic and healing properties without needle. Be certain to apply penetran plus twice a day: once each morning after bathing or showering and once each evening, before going to bed. While pentran plus often gives immediate relief consistently apply it twice a day at these particular times so that it will have a cumulative effect and produce much better results by the end of 30 to 60 days.